Journal of Advanced Periodontology & Implant Dentistry, Vol 7, No 1 (2015)

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The Effects of Obesity on Local and Circulating Levels of Tumor Necrosis Factor-α and Interleukin-6 in Patients with Chronic Periodontitis

Oguz Kose, Varol Canakci, Cenk Fatih Canakci, Abdulkadir Yildirim, Eda Kermen, Taner Arabaci, Adem Gungor

Abstract


Background and aims. The aim of this study was to evaluate the possible effects of obesity on the local (salivary) and systemic TNF-α and IL-6 levels in patients with chronic periodontitis (CP).
Materials and methods. This study included 88 subjects assigned to four groups of 22 subjects each, as follows: group O+P+ (patients with obesity and CP), group O-P+ (patients with normal weight and CP), group O+P- (periodontally healthy patients with obesity), and the control group, group O-P- (periodontally healthy patients with normal weight). Serum and salivary samples were obtained a week before the recording of clinical periodontal parameters. Local and systemic TNF-α and IL-6 levels were determined biochemically.
Results. In serum and saliva, both TNF-α and IL-6 levels were the lowest in O-P- group (P < 0.05). The highest TNF-α and IL-6 levels were observed in O+P+ group, while only IL-6 levels were statistically significant (P < 0.05).
Conclusion. Obesity upregulated the salivary and serum levels of TNF-α and IL-6. In patients with periodontitis, who were also obese, the serum and saliva levels of IL-6 were significantly high. Obesity might play a destructive and provocative role in the pathogenesis of periodontitis by negatively affecting IL-6 levels.

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JAPID ISSN 2008-7748 (print) 2008-7756 (online)
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